DATP(dGTP)—DNK purintransferaza
(Preusmjereno sa stranice DATP(dGTP)---DNA purinetransferase)
DATP(dGTP)—DNK purintransferaza (EC 2.6.99.1, DATP(dGTP)---DNA purinetransferase) je enzim sa sistematskim imenom dATP(dGTP):depurinisana-DNK purin transferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| DATP(dGTP)—DNK purintransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.99.1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) dATP + depurinated DNK dezoksiriboza trifosfat + DNK
- (2) dGTP + depurinated DNK dezoksiriboza trifosfat + DNK
Purinski ostatak se prenosi na apurinsko mesto, čime se formira normalna glikozilna veza.
Reference uredi
- ↑ Deutsch, W.A. and Linn, S. (1979). „DNA binding activity from cultured human fibroblasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites”. Proc. Natl. Acad. Sci. USA 76: 141-144. PMID 218192.
- ↑ Livneh, Z., Elad, D. and Sperling, J. (1979). „Enzymatic insertion of purine bases into depurinated DNA in vitro”. Proc. Natl. Acad. Sci. USA 76: 1089-1093. PMID 375225.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.