D-laktatna dehidrataza
D-laktatna dehidrataza (EC 4.2.1.130, glioksilaza III) je enzim sa sistematskim imenom (R)-laktat hidrolijaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| D-laktatna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.130 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (R)-laktat metilglioksal + H2O
Ovaj enzim konvertuje metilglioksal do D-laktata u jednom od glutationa (GSH) nezavisnom koraku.
Reference uredi
- ↑ Misra, K., Banerjee, A.B., Ray, S. and Ray, M. (1995). „Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione”. Biochem. J. 305: 999-1003. PMID 7848303.
- ↑ Subedi, K.P., Choi, D., Kim, I., Min, B. and Park, C. (2011). „Hsp31 of Escherichia coli K-12 is glyoxalase III”. Mol. Microbiol. 81: 926-936. PMID 21696459.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.