Cistinilna aminopeptidaza
Cistinilna aminopeptidaza (EC 3.4.11.3, cistil-aminopeptidaza, oksitocinaza, cistinska aminopeptidaza, L-cistinska aminopeptidaza, oksitocinska peptidaza, vazopresinaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Cistinilna aminopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.3 | ||||||||
| CAS broj | 9031-41-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Odvajanje N-terminalnih aminokiselina, Cys-Xaa-, gde je polovina cistinskog ostataka deo disulfidne petlje, posebno u oksitocinu ili vazopresinu. Brihine hidrolize aminoacil arilamida su veće od cistinil derivata.
Ovaj cinkov sijaloglikoprotein pripada peptidaznoj familiji M1 (membranskoj alanil aminopeptidaznoj familiji).
Reference uredi
- ↑ Sjöholm, I. (1967). „Biochemical studies on oxytocin and oxytocinase”. Acta Pharm. Suec. 4: 81-96. PMID 6041057.
- ↑ Sjöholm, I. and Yman, L. (1967). „Degradation of oxytocin, lysine vasopressin, angiotensin II, and angiotensin II amide by oxytocinase (cystine aminopeptidase)”. Acta Pharm. Suec. 4: 65-76. PMID 4292447.
- ↑ Yman, L. (1970). „Studies on human serum aminopeptidase. Some properties of oxytocinase, human serum aminopeptidase A and leucine aminopeptidase and their purification from retroplacental serum”. Acta Pharm. Suec. 7: 75-86. PMID 5421622.
- ↑ Sakura, H., Lin, T.Y., Doi, M., Mizutani, S. and Kawashima, Y. (1981). „Purification and properties of oxytocinase, a metalloenzyme”. Biochem. Int. 2: 173-179.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.