Astacin
Astacin (EC 3.4.24.21, Astacus proteinaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Astacin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.24.21 | ||||||||
| CAS broj | 143179-21-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Hidroliza peptidnih veza u supstratima koji sadrže pet ili više aminokiselina, preferentno sa Ala u P1', i Pro u P2'
Ova endopeptidaza varenja je prisutna u rakovima Astacus fluviatilis.
Reference uredi
- ↑ Krauhs, E., Dörsam, H., Little, M., Zwilling, R. and Ponstingl, H. (1982). „A protease from Astacus fluviatilis as an aid in protein sequencing”. Anal. Biochem. 119: 153-157. PMID 7041692.
- ↑ Titani, K., Torff, H.-J., Hormel, S., Kumar, S., Walsh, K.A., Rödl, J., Neurath, H. and Zwilling, R. (1987). „Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis”. Biochemistry 26: 222-226. PMID 3548817.
- ↑ Stöcker, W., Wolz, R.L., Zwilling, R., Strydom, D.J. and Auld, D.S. (1988). „Astacus protease, a zinc metalloenzyme”. Biochemistry 27: 5026-5032.
- ↑ Stöcker, W., Ng, M. and Auld, D.S. (1990). „Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease”. Biochemistry 29: 10418-10425. PMID 2261483.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
