Arabinofuranan 3-O-arabinoziltransferaza
Arabinofuranan 3-O-arabinoziltransferaza (EC 2.4.2.47, AftC) je enzim sa sistematskim imenom alfa-(1->5)-arabinofuranan:trans,oktacis-dekaprenilfosfo-beta-D-arabinofuranoza 3-O-alfa-D-arabinofuranoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Arabinofuranan 3-O-arabinoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.2.47 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Dodaje alfa-D-arabinofuranozilnu grupu sa trans,oktacis-dekaprenilfosfo-beta-D-arabinofuranoze u 3-O-poziciju alfa-(1->5)-arabinofurananskog lanca vezanog za beta-(1->5)-galaktofurananski lanac
Ovaj enzim je izolovan iz Mycobakterija smegmatis''. On učestvuje u formiranju ćelijskog zida mikobakterija.
Reference uredi
- ↑ Birch, H.L., Alderwick, L.J., Bhatt, A., Rittmann, D., Krumbach, K., Singh, A., Bai, Y., Lowary, T.L., Eggeling, L. and Besra, G.S. (2008). „Biosynthesis of mycobacterial arabinogalactan: identification of a novel α(1-→3) arabinofuranosyltransferase”. Mol. Microbiol. 69: 1191-1206. PMID 18627460.
- ↑ Zhang, J., Angala, S.K., Pramanik, P.K., Li, K., Crick, D.C., Liav, A., Jozwiak, A., Swiezewska, E., Jackson, M. and Chatterjee, D. (2011). „Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors”. ACS Chem. Biol. 6: 819-828. PMID 21595486.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.