Antocijanidin reduktaza
Antocijanidin reduktaza (EC 1.3.1.77, AtANR, MtANR) je enzim sa sistematskim imenom flavan-3-ol:NAD(P)+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Antocijanidin reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.77 | ||||||||
| CAS broj | 93389-48-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- flavan-3-ol + 2 NAD(P)+ antocianidin + 2 NAD(P)H + H+
Ovaj enzim formira 2,3-cis-flavan-3-ole. Izomerni 2,3-trans-flavan-3-oli se formiraju iz flavan-3,4-diola posredstvom enzima EC 1.17.1.3, leuoantocijanidin reduktaze. Enzim iz mahuna Medicago truncatula (MtANR) koristi NADPH i NADH kao reduktant, dok enzim iz biljke Arabidopsis thaliana (AtANR) koristi samo NADPH.
Reference uredi
- ↑ Xie, D.Y., Sharma, S.B., Paiva, N.L., Ferreira, D. and Dixon, R.A. (2003). „Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis”. Science 299: 396-399. PMID 12532018.
- ↑ Xie, D.Y., Sharma, S.B. and Dixon, R.A. (2004). „Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana”. Arch. Biochem. Biophys. 422: 91-102. PMID 14725861.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.