Alstonin

Alstonin
(IUPAC) ime
	(19α,20α)-16-(Metoksikarbonil)-19-metil-3,4,5,6,16,17-heksadehidro-18-oksajohimban-4-ium
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	441979
ChemSpider	149308
Hemijski podaci
Formula	C21H21N2O3
Mol. masa	349,402496 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=InChI=1S/C21H20N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-8,11-12,15-16H,9-10H2,1-2H3/p+1/t12-,15-,16-/m0/s1; Key: WYTGDNHDOZPMIW-RCBQFDQVSA-O
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Alstonin je indolni alkaloid i mogući antipsihotički sastojak raznih biljnih vrsta, uključujući Alstonia boonei, Catharanthus roseus, Picralima nitida, Rauwolfia caffra i Rauwolfia vomitoria.^[4] U prikliničkim ispitivanjima je pokazano da alstonin ublažuje hiperlokomociju indukovanu dejstvom MK-801, kao i deficit radne memorije i društveno povlačenje.^[5] U prikliničkim studijama je takođe pokazano da on ispoljava dejstva slična anksioliticima.^[4] On umanjuje amfetaminom indukovanu letalnost i stereotipnost, kao i apomorfinom indukovanu stereotipnost.^[4] On umanjuje haloperidolom indukovanu katalepsiju.^[6] Smatra se da su ta dejstva posredovana stimulacijom 5-HT_2C receptora.^[7] On takođe, slično klozapinu, inhibira ponovno preuzimanje glutamata u hipokampalnim režnjevima.^[8] Za razliku od klozapina, on ne manifestuje prokonvulzivno dejstvo kod miševa.^[9]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ ^4,0 ^4,1 ^4,2 Elisabetsky, E; Costa-Campos, L (March 2006). „The Alkaloid Alstonine: A Review of Its Pharmacological Properties” (PDF). Evidence-based Complementary and Alternative Medicine 3 (1): 39-48. DOI:10.1093/ecam/nek011. PMC 1375234. PMID 16550222.
↑ Linck, VM; Bessa, MM; Herrmann, AP; Iwu, MM; Okunji, CO; Elisabetsky, E (January 2012). „5-HT2A/C receptors mediate the antipsychotic-like effects of alstonine”. Progress in Neuro-Psychopharmacology and Biological Psychiatry 36 (1): 29-33. DOI:10.1016/j.pnpbp.2011.08.022. PMID 21925231.
↑ Linck, VM; Herrmann, AP; Piato, LN; Detanico, BC; Figueir, M; Flório, J; Iwu, MM; Okunji, CO; Leal, MB; Elisabetsky, E (July 2011). „Alstonine as an Antipsychotic: Effects on Brain Amines and Metabolic Changes” (PDF). Evidence-Based Complementary and Alternative Medicine 2011 (418597). DOI:10.1093/ecam/nep002.
↑ Gross, G; Geyer, MA, ur. (2012). Current Antipsychotics. Handbook of Experimental Pharmacology. 212. Springer Berlin Heidelberg. DOI:10.1007/978-3-642-25761-2. ISBN 978-3-642-25761-2. ISSN 1865-0325.
↑ Herrmann, AP; Lunardi, P; Pilz, LK; Tramontina, AC; Linck, VM; Okunji, CO; Gonçalves, CA; Elisabetsky, E (December 2012). „Effects of the putative antipsychotic alstonine on glutamate uptake in acute hippocampal slices”. Neurochemistry International 61 (7): 1144-1150. DOI:10.1016/j.neuint.2012.08.006. PMID 22940693.
↑ Costa-Campos L, Iwu M, Elisabetsky E (August 2004). „Lack of pro-convulsant activity of the antipsychotic alkaloid alstonine”. Journal of Ethnopharmacology 93 (2-3): 307-310. DOI:10.1016/j.jep.2004.03.056. PMID 15234769.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

Antipsychotic-Like Profile of Alstonine

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[pmc2006-4] 4,0 ^4,1 ^4,2 Elisabetsky, E; Costa-Campos, L (March 2006). „The Alkaloid Alstonine: A Review of Its Pharmacological Properties” (PDF). Evidence-based Complementary and Alternative Medicine 3 (1): 39-48. DOI:10.1093/ecam/nek011. PMC 1375234. PMID 16550222.

[5] Linck, VM; Bessa, MM; Herrmann, AP; Iwu, MM; Okunji, CO; Elisabetsky, E (January 2012). „5-HT2A/C receptors mediate the antipsychotic-like effects of alstonine”. Progress in Neuro-Psychopharmacology and Biological Psychiatry 36 (1): 29-33. DOI:10.1016/j.pnpbp.2011.08.022. PMID 21925231.

[6] Linck, VM; Herrmann, AP; Piato, LN; Detanico, BC; Figueir, M; Flório, J; Iwu, MM; Okunji, CO; Leal, MB; Elisabetsky, E (July 2011). „Alstonine as an Antipsychotic: Effects on Brain Amines and Metabolic Changes” (PDF). Evidence-Based Complementary and Alternative Medicine 2011 (418597). DOI:10.1093/ecam/nep002.

[7] Gross, G; Geyer, MA, ur. (2012). Current Antipsychotics. Handbook of Experimental Pharmacology. 212. Springer Berlin Heidelberg. DOI:10.1007/978-3-642-25761-2. ISBN 978-3-642-25761-2. ISSN 1865-0325.

[8] Herrmann, AP; Lunardi, P; Pilz, LK; Tramontina, AC; Linck, VM; Okunji, CO; Gonçalves, CA; Elisabetsky, E (December 2012). „Effects of the putative antipsychotic alstonine on glutamate uptake in acute hippocampal slices”. Neurochemistry International 61 (7): 1144-1150. DOI:10.1016/j.neuint.2012.08.006. PMID 22940693.

[9] Costa-Campos L, Iwu M, Elisabetsky E (August 2004). „Lack of pro-convulsant activity of the antipsychotic alkaloid alstonine”. Journal of Ethnopharmacology 93 (2-3): 307-310. DOI:10.1016/j.jep.2004.03.056. PMID 15234769.

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