Alazocin ((-)-SKF-10,047, (-)-N-alilnormetazocin, (-)-ANMC), je bio prvi lek koji je agonist σ1 receptora (Ki = 24 nM).[4][5][6] On nema značajan afinitet za σ2 receptor.[6] Alazocin takođe deluje kao agonist κ-opioidnog receptora (Ki = 0.4 nM), i u znatno manjoj meri kao antagonist NMDA receptora (Ki = 587 nM).[6][7]
Alazocin
|
(IUPAC) ime
|
(2R,6R,11R)- 6,11-dimethyl- 3-prop- 2-en- 1-yl- 1,2,3,4,5,6-hexahydro- 2,6-methano- 3-benzazocin- 8-ol 2-allyl- 5,9-dimethyl- 2'-hydroxy- 6,7-benzomorphan
|
Klinički podaci
|
Identifikatori
|
CAS broj
|
14198-28-8
|
ATC kod
|
nije dodeljen
|
PubChem[1][2]
|
3036246
|
ChemSpider[3]
|
2300306
|
Hemijski podaci
|
Formula
|
C17H23NO
|
Mol. masa
|
257.37 g/mol
|
SMILES
|
eMolekuli & PubHem
|
InChI |
InChI=1S/C17H23NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h4-6,11-12,16,19H,1,7-10H2,2-3H3/t12-,16+,17+/m0/s1 Y Key: LGQCVMYAEFTEFN-JCURWCKSSA-N Y |
|
Farmakoinformacioni podaci
|
Trudnoća
|
?
|
Pravni status
|
Uncontrolled
|
Način primene
|
?
|
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Iwamoto ET (February 1981). „Pharmacologic effects of N-allylnormetazocine (SKF-10047)”. NIDA research monograph 34: 82–8. PMID 6783955.
- ↑ Shearman GT, Herz A (August 1982). „Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat”. European journal of pharmacology 82 (3-4): 167–72. PMID 6290235.
- ↑ 6,0 6,1 6,2 Chou YC, Liao JF, Chang WY, Lin MF, Chen CF (March 1999). „Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan”. Brain Research 821 (2): 516–9. DOI:10.1016/S0006-8993(99)01125-7. PMID 10064839.
- ↑ Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J (2006). „Pharmacological profiles of opioid ligands at kappa opioid receptors”. BMC Pharmacology 6: 3. DOI:10.1186/1471-2210-6-3. PMC 1403760. PMID 16433932.