Adenozilkobinamid-fosfatna sintaza
Adenozilkobinamid-fosfatna sintaza (EC 6.3.1.10, CbiB) je enzim sa sistematskim imenom adenozilkobirinska kiselina:(R)-1-aminopropan-2-il fosfat ligaza (formira ADP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Adenozilkobinamid-fosfatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.1.10 | ||||||||
| CAS broj | 905988-16-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (1) ATP + adenozilkobirinska kiselina + (R)-1-aminopropan-2-il fosfat ADP + fosfat + adenozilkobinamid fosfat
- (2) ATP + adenozilkobirinska kiselina + (R)-1-aminopropan-2-ol ADP + fosfat + adenozilkobinamid
Jedan od supstrata ove reakcije, (R]-)-1-aminopropan-2-il fosfat, se formira posredstvom enzima CobD (EC 4.1.1.81, treonin-fosfat dekarboksilaze).
Reference uredi
- ↑ Cheong, C.G., Bauer, C.B., Brushaber, K.R., Escalante-Semerena, J.C. and Rayment, I. (2002). „Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica”. Biochemistry 41: 4798-4808. PMID 11939774.
- ↑ Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B12)”. Nat. Prod. Rep. 19: 390-412. PMID 12195810.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.