Aceklidin
Aceklidin (Glaukostat, Glaunorm, Glaudin) je parasimpatomimetički miotički agens koji se koristi za tretiranje glaukoma uskog ugla. On umanjuje intraokularni pritisak.
(IUPAC) ime | |||
---|---|---|---|
1-azabiciklo[2.2.2]oct-3-il acetat | |||
Klinički podaci | |||
AHFS/Drugs.com | Internacionalno ime leka | ||
Identifikatori | |||
CAS broj | 827-61-2 6109-70-2 (HCl) | ||
ATC kod | S01EB08 | ||
PubChem[1][2] | 1979 | ||
ChemSpider[3] | 1902 | ||
UNII | 0578K3ELIO | ||
KEGG[4] | D02750 | ||
ChEMBL[5] | CHEMBL20835 | ||
Hemijski podaci | |||
Formula | C9H15NO2 | ||
Mol. masa | 169,221 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | ℞ Prescription only | ||
Način primene | Ocularno |
Nepoželjna dejstva uredi
Nepoželjna dejstva aceklidina su povećana salivacija i bradikardija (pri primeni prekomernih doza).
Mehanizam dejstva uredi
Aceklidin deluje kao agonist muskarinskog acetilholinskog receptora.[6]
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Shannon HE, Hart JC, Bymaster FP, et al. (August 1999). „Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats”. J. Pharmacol. Exp. Ther. 290 (2): 901–7. PMID 10411607.