AS-19 je supstanca koja deluje kao potentan agonist 5HT7 receptora, sa EC50 od 0,83 nM. On poništava amneziju indukovanu lekovima kao što su skopolamin i dizocilpin i poboljšava dogotrajnu memoriju, ali inhibira formiranje kratkotrajne memorije.[4][5]
AS-19
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(IUPAC) ime
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(2S)-N,N-dimetil-5-(1,3,5-trimetilpirazol-4-il)-1,2,3,4-tetrahidronaftalen-2-amin
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Klinički podaci
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Identifikatori
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ATC kod
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nije dodeljen
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PubChem[1][2]
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23642275
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ChemSpider[3]
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24605931
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Hemijski podaci
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Formula
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C18H25N3
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Mol. masa
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283,411 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C18H25N3/c1-12-18(13(2)21(5)19-12)17-8-6-7-14-11-15(20(3)4)9-10-16(14)17/h6-8,15H,9-11H2,1-5H3/t15-/m0/s1 Y Key: BTTOYOKCLDAHHO-HNNXBMFYSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Meneses, A; Perez-Garcia, G; Liy-Salmeron, G; Flores-Galvez, D; Castillo, C; Castillo, E (2008). „The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation”. Behavioural Brain Research 195 (1): 112–9. DOI:10.1016/j.bbr.2007.11.023. PMID 18191236.
- ↑ Perez-García, G; Meneses, A (2008). „Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia”. Behavioural Brain Research 195 (1): 139–46. DOI:10.1016/j.bbr.2008.07.033. PMID 18723050.
Spoljašnje veze
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