ABT-670 je lek koji deluje kao potentan, oralno biodostupan dopaminski agonist koji je selektivan za D4 podtip. On je razvijen kao mogući tretman za impotenciju,[5] mada je njegova sadašnja primena ograničena na naučna istraživanja.[6]
ABT-670
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(IUPAC) ime
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3-metil-N-(1-oksi-3',4',5',6'-tetrahidro-2'H-[2,4'-bipiridin]-1'-ilmetil)benzamid
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Klinički podaci
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Identifikatori
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ATC kod
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nije dodeljen
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PubChem[1][2]
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16094676
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ChemSpider[3]
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17252978
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ChEMBL[4]
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CHEMBL219182 Y
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Hemijski podaci
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Formula
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C19H23N3O2
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Mol. masa
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325,404 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23) Y Key: PUMMPCXNEPHBNN-UHFFFAOYSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, Nelson SL, Cowart MD, Nakane M (2006). „Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-2,4'-bipyridine-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction”. Journal of medicinal chemistry 49 (25): 7450–65. DOI:10.1021/jm060662k. PMID 17149874.
- ↑ Richards N, Wayman C, Allers KA. Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection. Neuroscience Letters. 3 September 2009 DOI:10.1016/j.neulet.2009.08.078