A-366,833 je lek koji je razvilo preduzeće Abbott. On deluje kao agonist na neuronskom nikotinskim acetilholinskim receptorima. Selektivan je za α4β2 podtip, i izučavan je za moguću primenu kao analgetik, mada nije uspešno prošao kroz klinička ispitivanja.[5][6]
A-366,833
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(IUPAC) ime
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5-[(1S,5R)-3,6-diazabiciklo[3.2.0]hept-6-il]piridin-3-karbonitril
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Klinički podaci
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Identifikatori
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ATC kod
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nije dodeljen
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PubChem[1][2]
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9834234
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ChemSpider[3]
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8009955
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ChEMBL[4]
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CHEMBL239931 Y
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Hemijski podaci
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Formula
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C11H12N4
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Mol. masa
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200,239
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InChI |
InChI=1S/C11H12N4/c12-2-8-1-10(5-13-3-8)15-7-9-4-14-6-11(9)15/h1,3,5,9,11,14H,4,6-7H2/t9-,11-/m0/s1 Y Key: GPXAWLDGWSBLKM-ONGXEEELSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Ji, J.; Bunnelle, W.; Anderson, D.; Faltynek, C.; Dyhring, T.; Ahring, P.; Rueter, L.; Curzon, P. i dr.. (2007). „A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo3.2.0-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models”. Biochemical pharmacology 74 (8): 1253–1262. DOI:10.1016/j.bcp.2007.08.010. PMID 17854775.
- ↑ Romanelli, M.; Gratteri, P.; Guandalini, L.; Martini, E.; Bonaccini, C.; Gualtieri, F. (2007). „Central nicotinic receptors: structure, function, ligands, and therapeutic potential”. ChemMedChem 2 (6): 746–767. DOI:10.1002/cmdc.200600207. PMID 17295372.