8-Okso-dGTP difosfataza
8-okso-dGTP difosfataza (EC 3.6.1.55, MutT, 7,8-dihidro-8-oksoguanin trifosfataza, 8-okso-dGTPaza, 7,8-dihidro-8-okso-dGTP pirofosfohidrolaza) je enzim sa sistematskim imenom 8-okso-dGTP difosfohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 8-okso-dGTP difosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.55 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 8-okso-dGTP + H2O 8-okso-dGMP + difosfat
Ovaj enzim hidrolizuje fosfoanhidridnu vezu između alfa i beta fosfata nukleozida koji sadržie 8-oksoguanin.
Reference uredi
- ↑ Ito, R., Hayakawa, H., Sekiguchi, M. and Ishibashi, T. (2005). „Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools”. Biochemistry 44: 6670-6674. PMID 15850400.
- ↑ Yoshimura, K., Ogawa, T., Ueda, Y. and Shigeoka, S. (2007). „AtNUDX1, an 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate pyrophosphohydrolase, is responsible for eliminating oxidized nucleotides in Arabidopsis”. Plant Cell Physiol. 48: 1438-1449. PMID 17804481.
- ↑ Nakamura, T., Meshitsuka, S., Kitagawa, S., Abe, N., Yamada, J., Ishino, T., Nakano, H., Tsuzuki, T., Doi, T., Kobayashi, Y., Fujii, S., Sekiguchi, M. and Yamagata, Y. (2010). „Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base”. J. Biol. Chem. 285: 444-452. PMID 19864691.
- ↑ Yonekura, S., Sanada, U. and Zhang-Akiyama, Q.M. (2010). „CiMutT, an asidian MutT homologue, has a 7, 8-dihydro-8-oxo-dGTP pyrophosphohydrolase activity responsible for sanitization of oxidized nucleotides in Ciona intestinalis”. Genes Genet Syst 85: 287-295. PMID 21178309.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.