6-Piruvoiltetrahidropterinska sintaza
6-Piruvoiltetrahidropterinska sintaza (EC 4.2.3.12, 2-amino-4-okso-6-((1S,2R)-1,2-dihidroksi-3-trifosfooksipropil)-7,8-dihidroksipteridin trifosfat lijaza, 6-((1S,2R)-1,2-dihidroksi-3-trifosfooksipropil)-7,8-dihidropterin trifosfat-lijaza (formira 6-piruvoil-5,6,7,8-tetrahidropterin)) je enzim sa sistematskim imenom 7,8-dihidroneopterin 3'-trifosfat trifosfat-lijaza (formira 6-piruvoil-5,6,7,8-tetrahidropterin).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 6-Piruvoiltetrahidropterinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| 6-Piruvoiltetrahidropterinska sintaza homohexamer, Rattus rattus | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.2.3.12 | ||||||||
| CAS broj | 97089-82-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 7,8-dihidroneopterin 3'-trifosfat 6-piruvoil-5,6,7,8-tetrahidropterin + trifosfat
Ovaj enzim katalizuje trifosfatnu eliminaciju i intramolekularnu redoks reakciju u prisustvu jona Mg2+.
Reference uredi
- ↑ Milstien, S., Kaufman, S. (1989). „The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl-tetrahydrobiopterin(2′-oxo) reductase”. J. Biol. Chem. 264: 8066-8073. PMID 2656673.
- ↑ Thöny, B., Leimbacher, W., Bürgisser, D., Heinzmann, C.W. (1992). „Human 6-pyruvoyl-tetrahydrobiopterin synthase: cDNA cloning and heterologous expression of the recombinant enzyme”. Biochem. Biophys. Res. Commun. 189: 1437-1443. PMID 1282802.
- ↑ Supangat, S., Choi, Y.K., Park, Y.S., Son, D., Han, C.D. and Lee, K.H. (2005). „Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 202-204. PMID 16510994.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.