3a-hidroksisteroid dehidrogenaza (A-specifična)
3a-hidroksisteroid dehidrogenaza (A-specifična) (EC 1.1.1.213, 3alfa-hidroksisteroid dehidrogenaza, AKR1C2, Akr1c9) je enzim sa sistematskim imenom 3alfa-hidroksisteroid:NAD(P)+ 3-oksidoreduktaza (A-specifična).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3a-hidroksisteroid dehidrogenaza (A-specifična) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.213 | ||||||||
| CAS broj | 9028-56-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3 alfa-hidroksisteroid + NAD(P)+ 3-oksosteroid + NAD(P)H + H+
Ovaj enzim deluje na više 3alfa-hidroksisteroida. Nije specifičan u pogledu NAD+ ili NADP+ (cf. EC 1.1.1.50, 3alfa-hidroksisteroid 3-dehidrogenaza, B-specifična).
Reference uredi
- ↑ Björkhem, I. and Danielsson, H. (1970). „Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by Δ4-3-oxosteroid 5-β-reductase and 3-α-hydroxysteroid dehydrogenase from rat liver”. Eur. J. Biochem. 12: 80-84. PMID 4392180.
- ↑ Tomkins, G.M. (1956). „A mammalian 3α-hydroxysteroid dehydrogenase”. J. Biol. Chem. 218: 437-447. PMID 13278351.
- ↑ Dufort, I., Soucy, P., Labrie, F. and Luu-The, V. (1996). „Molecular cloning of human type 3 3α-hydroxysteroid dehydrogenase that differs from 20α-hydroxysteroid dehydrogenase by seven amino acids”. Biochem. Biophys. Res. Commun. 228: 474-479. PMID 8920937.
- ↑ Nahoum, V., Gangloff, A., Legrand, P., Zhu, D.W., Cantin, L., Zhorov, B.S., Luu-The, V., Labrie, F., Breton, R. and Lin, S.X. (2001). „Structure of the human 3α-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-Å resolution”. J. Biol. Chem. 276: 42091-42098. PMID 11514561.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.