24-Hidroksiholesterol 7α-hidroksilaza
24-Hidroksiholesterol 7α-hidroksilaza (EC 1.14.13.99, 24-hidroksiholesterol 7alfa-monooksigenaza, CYP39A1, CYP39A1 oksisterol 7alfa-hidroksilaza) je enzim sa sistematskim imenom (24R)-holest-5-en-3beta,24-diol,NADPH:kiseonik oksidoreduktaza (7alfa-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 24-Hidroksiholesterol 7α-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.99 | ||||||||
| CAS broj | 288309-90-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (24R)-holest-5-en-3beta,24-diol + NADPH + H+ + O2 (24R)-holest-5-en-3beta,7alfa,24-triol + NADP+ +H2O
Ovaj enzim je hem-tiolatni protein (P-450). On je prisutan u mikrozomima jetre i u cilijarnom nepigmentnom epitelijumu.
Reference uredi
- ↑ Li-Hawkins, J., Lund, E.G., Bronson, A.D. and Russell, D.W. (2000). „Expression cloning of an oxysterol 7α-hydroxylase selective for 24-hydroxycholesterol”. J. Biol. Chem. 275: 16543-16549. PMID 10748047.
- ↑ Ikeda, H., Ueda, M., Ikeda, M., Kobayashi, H. and Honda, Y. (2003). „Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye.”. Lab. Invest. 83: 349-355. PMID 12649335.
- ↑ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.