2-amino-4-dezoksihorizmat dehidrogenaza
2-amino-4-dezoksihorizmat dehidrogenaza (EC 1.3.99.24, ADIC dehidrogenaza, 2-amino-2-dezoksiizohorizmatna dehidrogenaza, SgcG) je enzim sa sistematskim imenom (2S)-2-amino-4-dezoksihorizmat:FMN oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2-amino-4-dezoksihorizmat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.99.24 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2S)-2-amino-4-dezoksihorizmat + FMN 3-(1-karboksiviniloksi)antranilat + FMNH2
Sekvencijalno dejstvo enzima EC 2.6.1.86, 2-amino-4-dezoksihorizmat sintaze i ovog enzima dovodi do formiranja benzoksazolinata od antitumornog antibiotika C-1027.
Reference uredi
- ↑ Van Lanen, S.G., Lin, S. and Shen, B. (2008). „Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism”. Proc. Natl. Acad. Sci. USA 105: 494-499. PMID 18182490.
- ↑ Yu, L., Mah, S., Otani, T. and Dedon, P. (1995). „The benzoxazolinate of C-1027 confers intercalative DNA binding”. J. Am. Chem. Soc. 117: 8877-8878.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.