2-Hidroksi-6-okso-6-(2-aminofenil)heksa-2,4-dienoatna hidrolaza
2-Hidroksi-6-okso-6-(2-aminofenil)heksa-2,4-dienoatna hidrolaza (EC 3.7.1.13, CarC) je enzim sa sistematskim imenom (2E,4E)-6-(2-aminofenil)-2-hidroksi-6-oksoheksa-2,4-dienoat acilhidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2-Hidroksi-6-okso-6-(2-aminofenil)heksa-2,4-dienoatna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.7.1.13 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2E,4E)-6-(2-aminofenil)-2-hidroksi-6-oksoheksa-2,4-dienoat + H2O antranilat + (2E)-2-hidroksipenta-2,4-dienoat
Ovaj enzim katalizuje treći korak u aerobnoj degradaciji karbazola.
Reference uredi
- ↑ Nojiri, H., Taira, H., Iwata, K., Morii, K., Nam, J.W., Yoshida, T., Habe, H., Nakamura, S., Shimizu, K., Yamane, H. and Omori, T. (2003). „Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain CA10”. Biosci. Biotechnol. Biochem. 67: 36-45. PMID 12619671.
- ↑ Riddle, R.R., Gibbs, P.R., Willson, R.C. and Benedik, M.J. (2003). „Purification and properties of 2-hydroxy-6-oxo-6-(2′-aminophenyl)hexa-2,4-dienoic acid hydrolase involved in microbial degradation of carbazole”. Protein Expr. Purif. 28: 182-189. PMID 12651123.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.