2,6-Dihidroksipseudooksinikotinska hidrolaza
2,6-Dihidroksipseudooksinikotinska hidrolaza (EC 3.7.1.19) je enzim sa sistematskim imenom 1-(2,6-dihidroksipiridin-3-il)-4-(metilamino)butan-1-on hidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2,6-Dihidroksipseudooksinikotinska hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.7.1.19 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 1-(2,6-dihidroksipiridin-3-il)-4-(metilamino)butan-1-on + H2O 2,6-dihidroksipiridin + 4-metilaminobutanoat
Ovaj enzim je izolovan iz zemljišne bakterije Arthrobacter nikotinovorans.
Reference uredi
- ↑ Gherna, R.L., Richardson, S.H. and Rittenberg, S.C. (1965). „The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine”. J. Biol. Chem. 240: 3669-3674. PMID 5835946.
- ↑ Sachelaru, P., Schiltz, E., Igloi, G.L. and Brandsch, R. (2005). „An α/β-fold C–C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans”. J. Bacteriol. 187: 8516-8519. PMID 16321959.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.