1,9-Pirazoloantron

1,9-Pirazoloantron
	2H-Dibenzo[cd,g]indazol-6-on
Drugi nazivi	Antra[1,9-cd]pirazol-6(2H)-on; Pirazolantron; Pirazoleantron; SP 600125; C.I. 70300; NSC 75890
Identifikacija
CAS registarski broj	129-56-6
PubChem	8515
ChemSpider	8201
DrugBank	DB01782
ChEMBL	CHEMBL7064
Jmol-3D slike	Slika 1; Slika 2
SMILES
	C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O O=C4c1cccc2c1c(nn2)c3ccccc34
InChI
	InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ; Kod: ACPOUJIDANTYHO-UHFFFAOYSA-N InChI=1/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16); Kod: ACPOUJIDANTYHO-UHFFFAOYAB
Svojstva
Molekulska formula	C14H8N2O
Molarna masa	220.23 g mol−1
Agregatno stanje	žut
Gustina	1,463 g cm−3
Tačka topljenja	281-282 °C, 554-555 K, 538-540 °F
Tačka ključanja	489 °C, 762 K, 912 °F
Rastvorljivost u vodi	nerastvoran
Opasnost
Tačka paljenja	246.8 °C
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

1,9-Pirazoloantron je hemijsko jedinjenje koje je derivat antrona. On se koristi u biohemijskim studijama kao inhbitor c-Jun N-terminalnih kinaza (JNK).^[5]

Derivati 1,9-porazoloantrona imaju više različitih bioloških dejstava. Na primer, 5-(aminoalkil)amino derivati su instraživani kao potencijalni tretmani za kancer.^[6]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Okuno S, Saito A, Hayashi T, Chan PH (2004). „The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia”. J. Neurosci. 24 (36): 7879–87. DOI:10.1523/JNEUROSCI.1745-04.2004. PMID 15356200.
↑ Showalter HD, Johnson JL, Werbel LM, Leopold WR, Jackson RC, Elslager EF (1984). „5-[(Aminoalkyl)amino]-substituted anthra[1,9-cd]pyrazol-6(2H)-ones as novel anticancer agents. Synthesis and biological evaluation”. J. Med. Chem. 27 (3): 253–5. DOI:10.1021/jm00369a002. PMID 6699870.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Okuno S, Saito A, Hayashi T, Chan PH (2004). „The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia”. J. Neurosci. 24 (36): 7879–87. DOI:10.1523/JNEUROSCI.1745-04.2004. PMID 15356200.

[6] Showalter HD, Johnson JL, Werbel LM, Leopold WR, Jackson RC, Elslager EF (1984). „5-[(Aminoalkyl)amino]-substituted anthra[1,9-cd]pyrazol-6(2H)-ones as novel anticancer agents. Synthesis and biological evaluation”. J. Med. Chem. 27 (3): 253–5. DOI:10.1021/jm00369a002. PMID 6699870.

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