Žučna kiselina-KoA:aminokiselina N-aciltransferaza
Žučna kiselina-KoA:aminokiselina N-aciltransferaza (EC 2.3.1.65, glicin-taurin N-aciltransferaza, amino kiselina N-holoiltransferaza, BAT, glicinska N-holoiltransferaza, BACAT, holil-KoA glicin-taurin N-aciltransferaza, holil-KoA:taurin N-aciltransferaza) je enzim sa sistematskim imenom holoil-KoA:glicin N-holoiltransferaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
Žučna kiselina-KoA:aminokiselina N-aciltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.3.1.65 | ||||||||
CAS broj | 65979-40-0 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- holoil-KoA + glicin KoA + glikoholat
Ovaj enzim takođe deluje na KoA derivate drugig žučnih kiselina. Taurin i 2-fluoro-beta-alanin mogu da deluju kao supstrati, mada sporije.
Reference uredi
- ↑ Czuba, B. and Vessey, D.A. (1980). „Kinetic characterization of cholyl-CoA glycine-taurine N-acyltransferase from bovine liver”. J. Biol. Chem. 255: 5296-5299. PMID 7372637.
- ↑ Jordan, T.W., Lee, R. and Lim, W.C. (1980). „Isoelectric focussing of soluble and particulate benzoyl-CoA and cholyl-CoA:amino acid N-acyltransferases from rat liver”. Biochem. Int. 1: 325-330.
- ↑ Vessey, D.A. (1979). „The co-purification and common identity of cholyl CoA:glycine- and cholyl CoA:taurine-N-acyltransferase activities from bovine liver”. J. Biol. Chem. 254: 2059-2063. PMID 422567.
- ↑ Johnson, M.R., Barnes, S., Kwakye, J.B. and Diasio, R.B. (1991). „Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver”. J. Biol. Chem. 266: 10227-10233. PMID 2037576.
- ↑ Falany, C.N., Xie, X., Wheeler, J.B., Wang, J., Smith, M., He, D. and Barnes, S. (2002). „Molecular cloning and expression of rat liver bile acid CoA ligase”. J. Lipid Res. 43: 2062-2071. PMID 12454267.
- ↑ He, D., Barnes, S. and Falany, C.N. (2003). „Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization”. J. Lipid Res. 44: 2242-2249. PMID 12951368.
- ↑ O'Byrne, J., Hunt, M.C., Rai, D.K., Saeki, M. and Alexson, S.E. (2003). „The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine”. J. Biol. Chem. 278: 34237-34244. PMID 12810727.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.